StressCovidV1, Main, Exploration, bibRecord, 000853

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.

Identifieur interne : 000853 ( Main/Exploration ); précédent : 000852; suivant : 000854

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.

Auteurs : Vu Van Loi [Allemagne] ; Nguyen Thi Thu Huyen [Allemagne] ; Tobias Busche [Allemagne] ; Quach Ngoc Tung [Allemagne] ; Martin Clemens Horst Gruhlke [Allemagne] ; Jörn Kalinowski [Allemagne] ; Jörg Bernhardt [Allemagne] ; Alan John Slusarenko [Allemagne] ; Haike Antelmann [Allemagne]

Source :

Free radical biology & medicine [ 1873-4596 ] ; 2019.

RBID : pubmed:31121222

Abstract

The prevalence of methicillin-resitant Staphylococcus aureus (MRSA) in hospitals and the community poses an increasing health burden, which requires the discovery of alternative antimicrobials. Allicin (diallyl thiosulfinate) from garlic exhibits broad-spectrum antimicrobial activity against many multidrug resistant bacteria. The thiol-reactive mode of action of allicin involves its S-thioallylations of low molecular weight (LMW) thiols and protein thiols. To investigate the mode of action and stress response caused by allicin in S. aureus, we analyzed the transcriptome signature, the targets for S-thioallylation in the proteome and the changes in the bacillithiol (BSH) redox potential (E_BSH) under allicin stress. Allicin caused a strong thiol-specific oxidative and sulfur stress response and protein damage as revealed by the induction of the PerR, HypR, QsrR, MhqR, CstR, CtsR, HrcA and CymR regulons in the RNA-seq transcriptome. Allicin also interfered with metal and cell wall homeostasis and caused induction of the Zur, CsoR and GraRS regulons. Brx-roGFP2 biosensor measurements revealed a strongly increased E_BSH under allicin stress. In the proteome, 57 proteins were identified with S-thioallylations under allicin treatment, including translation factors (EF-Tu, EF-Ts), metabolic and redox enzymes (AldA, GuaB, Tpx, KatA, BrxA, MsrB) as well as redox-sensitive MarR/SarA-family regulators (MgrA, SarA, SarH1, SarS). Phenotype and biochemical analyses revealed that BSH and the HypR-controlled disulfide reductase MerA are involved in allicin detoxification in S. aureus. The reversal of protein S-thioallylation was catalyzed by the Brx/BSH/YpdA pathway. Finally, the BSSB reductase YpdA was shown to use S-allylmercaptobacillithiol (BSSA) as substrate to regenerate BSH in S. aureus. In conclusion, allicin results in an oxidative shift of E_BSH and protein S-thioallylation, which can be reversed by YpdA and the Brx/BSH/YpdA electron pathways in S. aureus to regenerate thiol homeostasis.

DOI: 10.1016/j.freeradbiomed.2019.05.018
PubMed: 31121222

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.</title>
<author><name sortKey="Loi, Vu Van" sort="Loi, Vu Van" uniqKey="Loi V" first="Vu Van" last="Loi">Vu Van Loi</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huyen, Nguyen Thi Thu" sort="Huyen, Nguyen Thi Thu" uniqKey="Huyen N" first="Nguyen Thi Thu" last="Huyen">Nguyen Thi Thu Huyen</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Busche, Tobias" sort="Busche, Tobias" uniqKey="Busche T" first="Tobias" last="Busche">Tobias Busche</name>
<affiliation wicri:level="1"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Center for Biotechnology, Bielefeld University, D-33594, Bielefeld, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Center for Biotechnology, Bielefeld University, D-33594, Bielefeld</wicri:regionArea>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tung, Quach Ngoc" sort="Tung, Quach Ngoc" uniqKey="Tung Q" first="Quach Ngoc" last="Tung">Quach Ngoc Tung</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruhlke, Martin Clemens Horst" sort="Gruhlke, Martin Clemens Horst" uniqKey="Gruhlke M" first="Martin Clemens Horst" last="Gruhlke">Martin Clemens Horst Gruhlke</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kalinowski, Jorn" sort="Kalinowski, Jorn" uniqKey="Kalinowski J" first="Jörn" last="Kalinowski">Jörn Kalinowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Biotechnology, Bielefeld University, D-33594, Bielefeld, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Biotechnology, Bielefeld University, D-33594, Bielefeld</wicri:regionArea>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernhardt, Jorg" sort="Bernhardt, Jorg" uniqKey="Bernhardt J" first="Jörg" last="Bernhardt">Jörg Bernhardt</name>
<affiliation wicri:level="1"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Institute for Microbiology, University of Greifswald, D-17489, Greifswald, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Institute for Microbiology, University of Greifswald, D-17489, Greifswald</wicri:regionArea>
<wicri:noRegion>17489, Greifswald</wicri:noRegion>
<wicri:noRegion>17489, Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slusarenko, Alan John" sort="Slusarenko, Alan John" uniqKey="Slusarenko A" first="Alan John" last="Slusarenko">Alan John Slusarenko</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Antelmann, Haike" sort="Antelmann, Haike" uniqKey="Antelmann H" first="Haike" last="Antelmann">Haike Antelmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany. Electronic address: haike.antelmann@fu-berlin.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31121222</idno>
<idno type="pmid">31121222</idno>
<idno type="doi">10.1016/j.freeradbiomed.2019.05.018</idno>
<idno type="wicri:Area/PubMed/Corpus">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000207</idno>
<idno type="wicri:Area/PubMed/Curation">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000207</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000182</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000182</idno>
<idno type="wicri:Area/Ncbi/Merge">000A16</idno>
<idno type="wicri:Area/Ncbi/Curation">000A16</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A16</idno>
<idno type="wicri:Area/Main/Merge">000854</idno>
<idno type="wicri:Area/Main/Curation">000853</idno>
<idno type="wicri:Area/Main/Exploration">000853</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.</title>
<author><name sortKey="Loi, Vu Van" sort="Loi, Vu Van" uniqKey="Loi V" first="Vu Van" last="Loi">Vu Van Loi</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huyen, Nguyen Thi Thu" sort="Huyen, Nguyen Thi Thu" uniqKey="Huyen N" first="Nguyen Thi Thu" last="Huyen">Nguyen Thi Thu Huyen</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Busche, Tobias" sort="Busche, Tobias" uniqKey="Busche T" first="Tobias" last="Busche">Tobias Busche</name>
<affiliation wicri:level="1"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Center for Biotechnology, Bielefeld University, D-33594, Bielefeld, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Center for Biotechnology, Bielefeld University, D-33594, Bielefeld</wicri:regionArea>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tung, Quach Ngoc" sort="Tung, Quach Ngoc" uniqKey="Tung Q" first="Quach Ngoc" last="Tung">Quach Ngoc Tung</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruhlke, Martin Clemens Horst" sort="Gruhlke, Martin Clemens Horst" uniqKey="Gruhlke M" first="Martin Clemens Horst" last="Gruhlke">Martin Clemens Horst Gruhlke</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kalinowski, Jorn" sort="Kalinowski, Jorn" uniqKey="Kalinowski J" first="Jörn" last="Kalinowski">Jörn Kalinowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Biotechnology, Bielefeld University, D-33594, Bielefeld, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Biotechnology, Bielefeld University, D-33594, Bielefeld</wicri:regionArea>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>33594, Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernhardt, Jorg" sort="Bernhardt, Jorg" uniqKey="Bernhardt J" first="Jörg" last="Bernhardt">Jörg Bernhardt</name>
<affiliation wicri:level="1"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Institute for Microbiology, University of Greifswald, D-17489, Greifswald, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany; Institute for Microbiology, University of Greifswald, D-17489, Greifswald</wicri:regionArea>
<wicri:noRegion>17489, Greifswald</wicri:noRegion>
<wicri:noRegion>17489, Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slusarenko, Alan John" sort="Slusarenko, Alan John" uniqKey="Slusarenko A" first="Alan John" last="Slusarenko">Alan John Slusarenko</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Physiology, RWTH Aachen University, D-52056, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Antelmann, Haike" sort="Antelmann, Haike" uniqKey="Antelmann H" first="Haike" last="Antelmann">Haike Antelmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin, Germany. Electronic address: haike.antelmann@fu-berlin.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Freie Universität Berlin, Institute for Biology-Microbiology, D-14195, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Free radical biology & medicine</title>
<idno type="eISSN">1873-4596</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The prevalence of methicillin-resitant Staphylococcus aureus (MRSA) in hospitals and the community poses an increasing health burden, which requires the discovery of alternative antimicrobials. Allicin (diallyl thiosulfinate) from garlic exhibits broad-spectrum antimicrobial activity against many multidrug resistant bacteria. The thiol-reactive mode of action of allicin involves its S-thioallylations of low molecular weight (LMW) thiols and protein thiols. To investigate the mode of action and stress response caused by allicin in S. aureus, we analyzed the transcriptome signature, the targets for S-thioallylation in the proteome and the changes in the bacillithiol (BSH) redox potential (E<sub>BSH</sub>
) under allicin stress. Allicin caused a strong thiol-specific oxidative and sulfur stress response and protein damage as revealed by the induction of the PerR, HypR, QsrR, MhqR, CstR, CtsR, HrcA and CymR regulons in the RNA-seq transcriptome. Allicin also interfered with metal and cell wall homeostasis and caused induction of the Zur, CsoR and GraRS regulons. Brx-roGFP2 biosensor measurements revealed a strongly increased E<sub>BSH</sub>
 under allicin stress. In the proteome, 57 proteins were identified with S-thioallylations under allicin treatment, including translation factors (EF-Tu, EF-Ts), metabolic and redox enzymes (AldA, GuaB, Tpx, KatA, BrxA, MsrB) as well as redox-sensitive MarR/SarA-family regulators (MgrA, SarA, SarH1, SarS). Phenotype and biochemical analyses revealed that BSH and the HypR-controlled disulfide reductase MerA are involved in allicin detoxification in S. aureus. The reversal of protein S-thioallylation was catalyzed by the Brx/BSH/YpdA pathway. Finally, the BSSB reductase YpdA was shown to use S-allylmercaptobacillithiol (BSSA) as substrate to regenerate BSH in S. aureus. In conclusion, allicin results in an oxidative shift of E<sub>BSH</sub>
 and protein S-thioallylation, which can be reversed by YpdA and the Brx/BSH/YpdA electron pathways in S. aureus to regenerate thiol homeostasis.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Berlin</li>
<li>District de Cologne</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
<li>Berlin</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Berlin"><name sortKey="Loi, Vu Van" sort="Loi, Vu Van" uniqKey="Loi V" first="Vu Van" last="Loi">Vu Van Loi</name>
</region>
<name sortKey="Antelmann, Haike" sort="Antelmann, Haike" uniqKey="Antelmann H" first="Haike" last="Antelmann">Haike Antelmann</name>
<name sortKey="Bernhardt, Jorg" sort="Bernhardt, Jorg" uniqKey="Bernhardt J" first="Jörg" last="Bernhardt">Jörg Bernhardt</name>
<name sortKey="Busche, Tobias" sort="Busche, Tobias" uniqKey="Busche T" first="Tobias" last="Busche">Tobias Busche</name>
<name sortKey="Gruhlke, Martin Clemens Horst" sort="Gruhlke, Martin Clemens Horst" uniqKey="Gruhlke M" first="Martin Clemens Horst" last="Gruhlke">Martin Clemens Horst Gruhlke</name>
<name sortKey="Huyen, Nguyen Thi Thu" sort="Huyen, Nguyen Thi Thu" uniqKey="Huyen N" first="Nguyen Thi Thu" last="Huyen">Nguyen Thi Thu Huyen</name>
<name sortKey="Kalinowski, Jorn" sort="Kalinowski, Jorn" uniqKey="Kalinowski J" first="Jörn" last="Kalinowski">Jörn Kalinowski</name>
<name sortKey="Slusarenko, Alan John" sort="Slusarenko, Alan John" uniqKey="Slusarenko A" first="Alan John" last="Slusarenko">Alan John Slusarenko</name>
<name sortKey="Tung, Quach Ngoc" sort="Tung, Quach Ngoc" uniqKey="Tung Q" first="Quach Ngoc" last="Tung">Quach Ngoc Tung</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000853 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000853 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    StressCovidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31121222
   |texte=   Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31121222" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a StressCovidV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed May 6 16:44:09 2020. Site generation: Sun Mar 28 08:26:57 2021

Serveur d'exploration Stress et Covid

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Stress et Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.